Sexual maturity normally occurs between the ages of 6 and 12 months in Bullboxer Pit dogs, as it does in all canines. However, until they are at least 18 months to 2 years old, dogs shouldn't be bred. It's the appropriate thing to do to wait till they've finished growing up physically and psychologically.

Dogs normally have two mating seasons each year, in the spring and autumn. Female dogs experience "heat" or estrus at this time. The average length of a dog's heat cycle is 2–3 weeks, however, this may vary widely depending on breed.

When a female dog is in heat, the males get sexually aroused and may make an effort to mate with her. It cannot be stressed enough that breeding must never occur in an unregulated or irresponsible manner. The male and female canines must be both healthy and friendly. Furthermore, it is crucial to give serious thought to the hazards and obligations of breeding.

Dog breeding is a serious endeavour that calls for extensive familiarity with the science of breeding, the physical and mental well-being of the parent dogs, and a dedication to the welfare of the puppies produced.

Responsible breeding techniques are important because they protect the genetic purity of canine breeds and provide loving homes for the offspring.